“Never confuse a single defeat with a final defeat.” – F. Scott Fitzgerald

Nutraceuticals:

Luteolin

An antioxidant and anti-inflammatory flavonoid

Luteolin is a natural flavonoid found in many common vegetables and is known for its healthful properties.  However, while luteolin demonstrates significant pain and inflammation benefits in early research for pain,  clinical evidence in humans remains inadequate for definitive recommendations for supplementation.

 

See:

Luteolin

Luteolin is a natural flavonoid found in many plants like celery, broccoli, and parsley, known for its antioxidant, anti-inflammatory, and neuroprotective properties.  However, while luteolin demonstrates significant antinociceptive and anti-inflammatory effects in preclinical models of pain, particularly neuropathic and inflammatory pain,  clinical evidence in humans is currently lacking.

Mechanistically, luteolin’s analgesic effects involve activation of spinal GABAA and μ-opioid receptors, inhibition of glial cell and NLRP3 inflammasome activation, and suppression of p38 MAPK signaling in the spinal dorsal horn. These actions reduce neuroinflammation and central sensitization, key drivers of chronic pain.

• Luteolin appears to be an excellent candidate for alleviating pain in chronic inflammatory conditions (e.g., rheumatoid arthritis, osteoarthritis, inflammatory bowel disease), inhibiting major inflammatory mediators involved in manifestation of pain as a symptom of the disease.

• Based on its strong anti-inflammatory and antioxidant properties shown in preclinical studies, luteolin can inhibit the major components of pain pathogenesis in neuropathy, namely oxidative stress and neuroinflammation, that lead to nerve damage and chronic pain.

• Based on preclinical and clinical studies demonstrating anti-inflammatory and analgesic properties of Palmitoylethanolamide (PEA), luteolin has a potential beneficial synergism with PEA .

• Luteolin appears (from preclinical and clinical data) to have a very good safety profile, making it even more appealing for clinical implementation.

In summary, luteolin has strong preclinical evidence for pain relief via antioxidant, anti-inflammatory, and neuroprotective mechanisms, but high-quality clinical trials in pain populations are needed to confirm its efficacy in humans. Plants rich in luteolin have been used as Chinese traditional medicine for hypertension, inflammatory diseases, and cancer. At this time supplementing with luteolin products may best be deferred in favor of eating plenty of foods rich in luteolin such as:

    • celery
    • parsley
    • broccoli
    • onion leaves
    • carrots
    • peppers
    • cabbages
    • apple skins

Purchasing Supplements

When purchasing supplements reviewed on this web site and discussed with Dr. Ehlenberger, a discount on usual commercial pricing can be obtained by purchasing from Accurate Clinic’s online Supplement Store after acquiring the discount code from Accurate Clinic:

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 or call Toll-Free: 877-846-7122 (Option 1)

 

References:

Quercetin –  Overviews

  1. Quercetin | University of Maryland Medical Center
  2.  Quercetin Attenuates Inflammatory Responses in BV-2 Microglial Cells
  3. Quercetin and derivatives: useful tools in inflammation and pain management. – PubMed – NCBI

 

Quercetin – COVID-19

  1. Quercetin and Vitamin C – An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19) – 2020
  2. Quercetin Is More Effective than Cromolyn in Blocking Human Mast Cell Cytokine Release and Inhibits Contact Dermatitis and Photosensitivity in Humans – 2012
  3. Quercetin Inhibits the Production of IL-1β-Induced Inflammatory Cytokines and Chemokines in ARPE-19 Cells via the MAPK and NF-κB Signaling Pathways – 2020
  4. Quercetin and Its Anti-Allergic Immune Response – 2016

 

Quercetin – COMT inhibitor

  1.  Phytochemicals Inhibit Catechol-O-Methyltransferase Activity in Cytosolic Fractions from Healthy Human Mammary Tissues – Implications for Catechol Estrogen-Induced DNA Damage – 2004

 

Quercetin – Drug Interactions

  1. Overview of P-glycoprotein inhibitors – a rational outlook – 2012
  2. Emerging Significance of Flavonoids as P-Glycoprotein Inhibitors in Cancer Chemotherapy – 2009
  3. Herbal modulation of P-glycoprotein. [Drug Metab Rev. 2004] – PubMed – NCBI

 

Quercitin – Green tea

  1. Quercetin increased bioavailability and decreased methylation of green tea polyphenols in vitro and in vivo

 

Quercetin – Liver Disease

  1. Antioxidants in liver health – 2015

 

Quercetin – Nanoformulations

  1. Quercetin – Natural Medicines – Professional

Emphasis on Education

 

Accurate Clinic promotes patient education as the foundation of it’s medical care. In Dr. Ehlenberger’s integrative approach to patient care, including conventional and complementary and alternative medical (CAM) treatments, he may encourage or provide advice about the use of supplements. However, the specifics of choice of supplement, dosing and duration of treatment should be individualized through discussion with Dr. Ehlenberger. The following information and reference articles are presented to provide the reader with some of the latest research to facilitate evidence-based, informed decisions regarding the use of conventional as well as CAM treatments.

 

For medical-legal reasons, access to these links is limited to patients enrolled in an Accurate Clinic medical program.

 

Should you wish more information regarding any of the subjects listed – or not listed –  here, please contact Dr. Ehlenberger. He has literally thousands of published articles to share on hundreds of topics associated with pain management, weight loss, nutrition, addiction recovery and emergency medicine. It would take years for you to read them, as it did him.

 

For more information, please contact Accurate Clinic.

 

Supplements recommended by Dr. Ehlenberger may be purchased commercially online or at Accurate Clinic.

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