Accurate Supplements – Niacel (nicotinamide riboside)

Niacel (Nicotinamide Riboside)

60 tabs

   Accurate retail: $41.23

   Thorne retail: $48.50

 

Ingredients

One Capsule Contains:

Nicotinamide Riboside Chloride* 125 mg

Other Ingredients:

Hypromellose (derived from cellulose) capsule, Microcrystalline Cellulose, Leucine, Silicon Dioxide.

This product contains ChromaDex Inc.’s proprietary Nicotinamide Riboside ingredient, Niagen®. Niagen is a registered trademark of ChromaDex, Inc.

 

  1. Nicotinamide riboside to promote endurance, energy, and healthy aging*
  2. Supports cognitive function and nerve protection*
  3. Helps stimulate thermogenesis (fat burning)*
  4. Promotes endurance and efficiency of skeletal and heart muscle*
  5. Supports healthy aging through activation of proteins called sirtuins*

 

See also:

Mitochondrial Dysfunction

NRF2 Activators

 

 

For an in-depth webinar on Nicotinamide Riboside:

Nicotinamide Riboside webinar

NiaCel-small

Nicotinamide riboside (NR) – Brief Description

Nicotinamide riboside (NR) is the most direct precursor to nicotinamide adenine dinucleotide (NAD+).* NAD+ is a key component of the citric acid cycle and the electron transport chain, both involved in mitochondrial production of ATP for energy.*

In addition to its importance in cellular energy production, NAD+ is a critical substrate for several enzymes, including sirtuins (SIRT1 and SIRT3, in particular), which play key roles in healthy aging, weight management, metabolic syndrome, and hepatic lipid metabolism.*

 

What health benefits does NiaCel provide?

 

  1. NiaCel supports insulin sensitivity*
  2. NiaCel promotes healthy aging by turning on sirtuins, which increases mitochondrial biogenesis*
  3. NiaCel is neuroprotective and supports cognitive function*
  4. NiaCel supports weight management by promoting thermogenesis*1
  5. NiaCel benefits endurance athletes and fatigued individuals by increasing muscle and cardiac mitochondria*

 

For more information regarding the role Nicotinamide Riboside (NR)  in maintaining health and energy, NR in context of the aging process and it’s potential role in the prevention and/or treatment of the conditions of stress, fatigue, diabetes, obesity, cardiovascular disease and fibromyalgia, please read more about “Mitochondrial Dysfunction.”

 

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

 

1. Canto C, Houtkooper R, Pirinen E, et al. The NAD+ precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metab 2012;15:838-847

 

References:

NAD/NR –  Overview

  1. Caloric Restriction, Fasting and Nicotinamide Riboside | Anti-Aging | Articles | Magazine
  2. First-human-clinical-study-of-ChromaDexs-NIAGEN-nicotinamide-riboside-meets-primary-endpoint
  3. Nicotinamide riboside, a trace nutrient in foods, is a vitamin B3 with effects on energy metabolism and neuroprotection. – PubMed – NCBI
  4. The Secret Life of NAD+: An Old Metabolite Controlling New Metabolic Signaling Pathways – 2010
  5. NAD+ metabolism in health and disease. – PubMed – NCBI
  6. NAD+ and Sirtuins in Aging and Disease – 2014
  7. NAD+ Metabolism and the Control of Energy Homeostasis – A Balancing Act between Mitochondria and the Nucleus
  8. NAD+ and NADH in brain functions, brain diseases and brain aging. – PubMed – NCBI

 

NAD/NR – Aging

  1. Vitamins and Aging – Pathways to NAD+ Synthesis – 2007
  2. A New, Reversible, Cause of Aging | HMS

 

NAD/NR – Brain Inflammation

  1. Treatment of Brain Inflammatory Diseases by Delivering Exosome Encapsulated Anti-inflammatory Drugs From the Nasal Region to the Brain – 2011

 

NAD/NR – Fibromyalgia

  1. The role of mitochondrial dysfunctions due to oxidative and nitrosative stress in the chronic pain or chronic fatigue syndromes and fibromyalgia patients – 2013

 

NAD/NR – Intranasal

  1. NAD+ and NADH in cellular functions and cell death. – PubMed – NCBI

 

NAD/NR – Mitochondrial disorders

  1. The role of mitochondrial dysfunctions due to oxidative and nitrosative stress in the chronic pain or chronic fatigue syndromes and fibromyalgia patients – 2013
  2. NAD+ Metabolism and the Control of Energy Homeostasis – A Balancing Act between Mitochondria and the Nucleus
  3. Pharmacological NAD-Boosting Strategies Improve Mitochondrial Homeostasis in Human Complex I-Mutant Fibroblasts. – PubMed – NCBI

 

NAD/NR – Obesity

  1. The NAD+ precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet induced obesity – 2012
  2. Milk Ingredient Nicotinamide Riboside ‘Helps Prevent Obesity’ And Burns Fat
  3. Niagen nicotinamide riboside may reduce obesity-related inflammation

 

NAD/NR – Oxidative Stress and Reactive Oxygen Species (ROS)

  1. Crosstalk between Oxidative Stress and SIRT1 – Impact on the Aging Process – 2013
  2. Reactive oxygen species and mitochondria – A nexus of cellular homeostasis – 2015

 

NAD/NR – Sirtuins

  1. Nicotinamide Riboside Promotes Sir2 Silencing and Extends Lifespan via Nrk + and Urh1:Pnp1:Meu1 Pathways to NAD -2007
  2. SIRTUIN 1 AND SIRTUIN 3 – PHYSIOLOGICAL MODULATORS OF METABOLISM – 2012
  3. Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging – 2013
  4. Targeting SIRT1 to improve metabolism – all you need is NAD+? – 2012

 

Emphasis on Education

 

Accurate Clinic promotes patient education as the foundation of it’s medical care. In Dr. Ehlenberger’s integrative approach to patient care, including conventional and complementary and alternative medical (CAM) treatments, he may encourage or provide advice about the use of supplements. However, the specifics of choice of supplement, dosing and duration of treatment should be individualized through discussion with Dr. Ehlenberger. The following information and reference articles are presented to provide the reader with some of the latest research to facilitate evidence-based, informed decisions regarding the use of conventional as well as CAM treatments.

 

For medical-legal reasons, access to these links is limited to patients enrolled in an Accurate Clinic medical program.

 

Should you wish more information regarding any of the subjects listed – or not listed –  here, please contact Dr. Ehlenberger. He has literally thousands of published articles to share on hundreds of topics associated with pain management, weight loss, nutrition, addiction recovery and emergency medicine. It would take years for you to read them, as it did him.

 

For more information, please contact Accurate Clinic.

 

Supplements recommended by Dr. Ehlenberger may be purchased commercially online or at Accurate Clinic.

Please read about our statement regarding the sale of products recommended by Dr. Ehlenberger.

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