Accurate Supplements – Palmitoylethanolamide (PEA)

Palmitoylethanolamide (PEA)


It appears the only place to purchase PEA, as “PeaPure,” is online from the Netherlands. The website, offers capsules and a topical cream.

Perhaps the most informative website on PEA is
I have no experience, first or second-hand, with either of these web site other than reviewing their content.

PeaPure capsulesPeaPure cream


30 vegetarian capsules
Ingredients: palmitoylethanolamide, hydroxypropyl methylcellulose (capsule)
Each capsule contains 400 mg palmitoylethanolamide (PEA).

Product Description

Description of PeaPure® capsules

PeaPure® is a food supplement based on a natural and fatty-acid like compound.
The substance palmitoylethanolamide (PEA) is a physiologically active molecule that the body produces naturally. Patent on formulation pending.

What the user should know prior to ingestion:

There are no known significant side effects.

PeaPure® can be taken simultaneously with other medicine. In case of doubt, it is recommended to first consult your doctor or a pharmacist.

Use during pregnancy is NOT recommended.

PeaPure® does not contain sugar, yeast, allergens, sorbitol, magnesium stearate, povidone or other ingredients.

Dosage and administration

Administration: During or after the meal, swallow 1 capsule together with water, or sprinkle the content of the capsule on your food.

First 2 months:  1 capsule 3 times daily
Next 2 months: In case of a positive result,  1 capsule 2 times daily

After 4 months, you can consider the following:

Continue taking 2 times 1 capsule daily.

Reduce the ingestion to 1 times 1 capsule daily.

Stop the ingestion.

In case of regression, it is recommended to increase the dosage to 2 or 3 times 1 capsule daily. It is possible to continue taking PeaPure® in the correct dosage.
Do not exceed the recommended daily dosage.*

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Palmitoylethanolamide (PEA) Overview

Palmitoylethanolamide (PEA), an endogenous fatty acid amide, is emerging as a new agent in the treatment of pain and inflammation. The compound was used many decades ago in other countries, but since the 1990s, interest has surged again. It is classified as a food for medical purposes or as a diet supplement in various countries of Europe.


PEA has shown effectiveness in many different preclinical animal studies for chronic and neuropathic pain, and most importantly effectiveness in reducing pain in various human clinical trials. Human studies demonstrate PEA to be effective for different types of pain, including nerve pain, inflammatory pain and visceral pain such as endometriosis and interstitial cystitis. Clinical benefits have been shown for fibromyalgia,  peripheral neuropathies such as diabetic neuropathy, chemotherapy-induced peripheral neuropathy, carpal tunnel syndrome, sciatic pain, osteoarthritis, low-back pain, failed back surgery syndrome, dental pains, neuropathic pain in stroke and multiple sclerosis, chronic pelvic pain, postherpetic neuralgia, and rectal and vaginal pains.


Probably related to the fact that PEA is endogenous (manufactured by the body) and a compound found in foods such as eggs and milk, no serious side effects or drug–drug interactions been identified.


Reference Publications


Palmitoylethanolamide (PEA)

PEA – Overview

  1. Therapeutic utility of palmitoylethanolamide in the treatment of neuropathic pain associated with various pathological conditions – 2012
  2. Chronic Pain in the Elderly – The Case for New Therapeutic Strategies – 2015
  3. Information for MDs and Pharmacists on Palmitoylethanolmide


PEA – Availability

Not available in USA, must be ordered on line from the Netherlands, see above


PEA – Anti-inflammatory

  1. Palmitoylethanolamide “PEA” – Review of Anti-inflammatory, Analgesic, Neuroprotective Mechanisms
  2. Palmitoylethanolamide (PEA) – Boosting Its Anti-inflammatory Immune Response


PEA – Anxiety and Depression

  1. Effects of palmitoylethanolamide and luteolin in an animal model of anxiety:depression. – PubMed – NCBI


PEA – Carpal Tunnel Syndrome

  1. Use of palmitoylethanolamide in the entrapment neuropathy of the me… – PubMed – NCBI


PEA – Central Sensitivity,  Oxidative Stress and Pain

  1. Palmitoylethanolamide in CNS health and disease. – PubMed – NCBI
  2. Palmitoylethanolamide reduces pain-related behaviors and restores glutamatergic synapses homeostasis in the medial prefrontal cortex of neuropathic mice – 2015


PEA – Colds and Flu

  1. Palmitoylethanolamide – A Natural Body-Own Anti-Inflammatory Agent, Effective and Safe against Influenza and Common Cold – 2013


PEA – CRPS (Chronic Regional Pain Syndrome)

  1. Treatment of chronic regional pain syndrome type 1 with palmitoylethanolamide and topical ketamine cream – 2013


PEA – Fibromyalgia

  1. Palmitoylethanolamide in Fibromyalgia – Results from Prospective and Retrospective Observational Studies – 2015


PEA –Headaches (Migraine)

  1. PeaPure – Palmitoylethanolamide for Nerve Pain or Migraine


PEA – Neuropathic Pain

  1. Microglia in the spinal cord and neuropathic pain – 2016
  2. Can modulating inflammatory response be a good strategy to treat neuropathic pain? – PubMed – NCBI
  3. Glia and mast cells as targets for palmitoylethanolamide, an anti-inflammatory and neuroprotective lipid mediator. – PubMed – NCBI
  4. Chronic-idiopathic-axonal-neuropathy-and-pain–treated-with-PEA
  5. Non-neuronal cell modulation relieves neuropathic pain: efficacy of the endogenous lipid palmitoylethanolamide. – PubMed – NCBI
  6. Palmitoylethanolamide Is a Disease-Modifying Agent in Peripheral Neuropathy – Pain Relief and Neuroprotection Share a PPAR-Alpha-Mediated Mechanism
  7. Peroxisome proliferator-activated receptor agonists modulate neuropathic pain – 2014
  8. Short-Term Efficacy of Ultramicronized Palmitoylethanolamide in Peripheral Neuropathic Pain
  9. Micronized Palmitoylethanolamide Reduces the Symptoms of Neuropathic Pain in Diabetic Patients
  10. Palmitoylethanolamide restores myelinated-fibre function in patient… – PubMed – NCBI
  11. delay-of-morphine-tolerance-by-palmitoylethanolamide-2015


PEA – Visceral Pain, Endometriosis

  1. The adjuvant use of N-palmitoylethanolamine and transpolydatin in the treatment of endometriotic pain – 2013
  2. Effectiveness of the association micronized N-Palmitoylethanolamine (PEA)- transpolydatin in the treatment of chronic pelvic pain related to endometriosis – 2011


PEA – Micronization Product Formulations

  1. A new co-ultramicronized composite including palmitoylethanolamide and luteolin to prevent neuroinflammation in spinal cord injury
  2. Micronization: a method of improving the bioavailability of poorly soluble drugs. – PubMed – NCBI


PEA – Morphine Tolerance

  1. Delay of morphine tolerance by palmitoylethanolamide


PEA – Proctodynia and Vulvodynia

  1. Vulvodynia & proctodynia treated with topical baclofen 5 % & palmitoylethanolamide | Pain Management Specialist in San Diego & La Jolla


PEA – Pudendal Neuralgia

  1. Misdiagnosed chronic pelvic pain: pudendal neuralgia responding to … – PubMed – NCBI

Emphasis on Education


Accurate Clinic promotes patient education as the foundation of it’s medical care. In Dr. Ehlenberger’s integrative approach to patient care, including conventional and complementary and alternative medical (CAM) treatments, he may encourage or provide advice about the use of supplements. However, the specifics of choice of supplement, dosing and duration of treatment should be individualized through discussion with Dr. Ehlenberger. The following information and reference articles are presented to provide the reader with some of the latest research to facilitate evidence-based, informed decisions regarding the use of conventional as well as CAM treatments.


For medical-legal reasons, access to these links is limited to patients enrolled in an Accurate Clinic medical program.


Should you wish more information regarding any of the subjects listed – or not listed –  here, please contact Dr. Ehlenberger. He has literally thousands of published articles to share on hundreds of topics associated with pain management, weight loss, nutrition, addiction recovery and emergency medicine. It would take years for you to read them, as it did him.


For more information, please contact Accurate Clinic.


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