Vitamin B12

See also:

Nutrition & Supplements

Vitamin Recommend Diet Allowance (RDA)

Vitamin D



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Vitamin B12

Reference Publications

Vitamin B12 – New Articles

  1. Effect of Diclofenac with B Vitamins on the Treatment of Acute Pain Originated by Lower-Limb Fracture and Surgery copy Vitamin B12 – Health Professional Fact Sheet – 2021
  2. B vitamins suppress spinal dorsal horn nociceptive neurons in the cat – PubMed – 1988
  3. Effects of acetyl‐L‐carnitine and methylcobalamin for diabetic peripheral neuropathy – A multicenter, randomized, double‐blind, controlled trial – 2016
  4. Efficacy and Safety of the Combination of Superoxide Dismutase, Alpha Lipoic Acid, Vitamin B12, and Carnitine for 12 Months in Patients with Diabetic Neuropathy – 2020
  5. Methylcobalamin-A-Potential-Vitamin-of-Pain-Killer Vitamin B12 as a Treatment for Pain – 2019


Vitamin B12 – Overview

  1. Vitamin B12 in Health and Disease
  2. Dietary Supplement Fact Sheet: Vitamin B12 — Health Professional Fact Sheet


Vitamin B12 – Botox

  1.  Does Vitamin B Alter the Efficacy of Botulinum Toxin?

Vitamin B12 – Administration

  1. Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency
  2. Intranasal cyanocobalamin – an effective and safe therapeutic alternative

Vitamin B12 – Deficiency

  1. Update on Vitamin B12 Deficiency
  2. Vegetarian lifestyle and monitoring of vitamin B-12 status. – PubMed – NCBI

Vitamin B12 Deficiency – Metformin

  1. Metformin associated B12 deficiency. – PubMed – NCBI
  2. Metformin and vitamin B12 deficiency – the role of H2 receptor antagonists and proton pump inhibitors
  3. Vitamin B12 deficiency associated with high doses od metformin in older people diabetic
  4. Vitamin B12 Status in Metformin Treated Patients – Systematic Review

Vitamin B12 Deficiency – Proton Pump Inhibitors (PPIs)

  1. Metformin With Either Histamine H2-Receptor Antagonists or Proton Pump Inhibitors: A Polypharmacy Recipe for Neuropathy via Vitamin B12 Depletion. – PubMed – NCBI
  2. Metformin and vitamin B12 deficiency – the role of H2 receptor antagonists and proton pump inhibitors
  3. potential gastrointestinal effects of long-term acid suppression with proton pump inhibitors


Vitamin B12 – Depression

  1. Vitamin B12 Deficiency and Depression in the Elderly: Review and Case Report
  2. Effects of high-dose B vitamin complex with vitamin C and minerals on subjective mood and performance in healthy males
  3. Longitudinal association of vitamin B-6, folate, and vitamin B-12 with depressive symptoms among older adults over time

Vitamin B12 – Low Back Pain

  1. Intramuscular Vitamin B12 Injections for Treating Chronic Low Back Pain
  2. Methylcobalamin – A Potential Vitamin of Pain Killer
  3. The efficacy and safety of intramuscular injections of methylcobalamin in patients with chronic nonspecific low back pain – a randomised controlled trial.
  4. Vitamin B12 7 LBP
  5. Vitamin B12 in low back pain: a randomised, double-blind, placebo-controlled study. – PubMed – NCBI
  6. Methylcobalamin as an adjuvant medication in conservative treatment of lumbar spinal stenosis. – PubMed – NCBI


Vitamin B12 – Pain

  1. Methylcobalamin – A Potential Vitamin of Pain Killer


Vitamin B12 – Peripheral Neuropathy

  1. Effectiveness of vitamin B12 on diabetic neuropathy: systematic review of clinical controlled trials – PubMed Health
  2. Effects of methylcobalamin on diabetic neuropathy. – PubMed – NCBI
  3. Improvement of cutaneous sensitivity in diabetic peripheral neuropathy with combination L-methylfolate, methylcobalamin, and pyridoxal 5′-phosphate. – PubMed – NCBI
  4. Meta-analysis of methylcobalamin alone and in combination with lipoic acid in patients with diabetic peripheral neuropathy. – PubMed – NCBI
  5. Metanx in type 2 diabetes with peripheral neuropathy: a randomized trial. – PubMed – NCBI
  6. Vitamin B12 may be more effective than nortriptyline in improving painful diabetic neuropathy. – PubMed – NCBI


Vitamin B12 – Optimal Levels

  1. Optimal serum 25-hydroxyvitamin D levels for multiple health outcomes. 2014 – PubMed – NCBI

Emphasis on Education


Accurate Clinic promotes patient education as the foundation of it’s medical care. In Dr. Ehlenberger’s integrative approach to patient care, including conventional and complementary and alternative medical (CAM) treatments, he may encourage or provide advice about the use of supplements. However, the specifics of choice of supplement, dosing and duration of treatment should be individualized through discussion with Dr. Ehlenberger. The following information and reference articles are presented to provide the reader with some of the latest research to facilitate evidence-based, informed decisions regarding the use of conventional as well as CAM treatments.


For medical-legal reasons, access to these links is limited to patients enrolled in an Accurate Clinic medical program.


Should you wish more information regarding any of the subjects listed – or not listed –  here, please contact Dr. Ehlenberger. He has literally thousands of published articles to share on hundreds of topics associated with pain management, weight loss, nutrition, addiction recovery and emergency medicine. It would take years for you to read them, as it did him.


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